Modern achievements of Khabarovsk research institute of epidemiology and microbiology led to improvement of available and development of new scientific and practical aspects of epidemiology, diagnostics and prevention of some infectious and parasitic diseases, which are topical for the Far Eastern Federal District of the Russian Federation. Currently all these scientific trends develop fast and generally applied. Successes of Khabarovsk research institute of epidemiology and microbiology during the past few years and perspectives of future development are due to significant modernization of material and technical support favor the resolution of scientific and of practical goals.

The analysis of morbidity of acute intestinal viral infections among three administrative districts of Khabrovsk Krai in 2015 is presented in this article. The factors that led to the development of epidemic foci were revealed. The leading factor was unsatisfactory condition of water supply system. Cause-and-effect relations between pollution of drinking water and outbreaks of acute intestinal viral (norovirus and rotovirus) infections in Khabarovsk Krai were revealed. The major preventive majors were described.

The quality of water resources based on territorial belonging of water resources on the territory of Amur Oblast was evaluated for the first time. Several important waterborne acute intestinal infections such as rotovirus infection, norovirus infection and enterovirus infection was revealed based on retrospective and operational analysis. We found that Blagoveshchensk city and southern zone of Amur Oblast are situated on the territory of high risk for waterborne acute intestinal infections. Strong and moderate correlation between quality of drinking water and morbidity rate among patients with acute intestinal infections was found. This correlation became stronger in the flood of 2013.

Isolates of not fermenting bacteria (NFB) from hospitals of Rostov-on-Don are studied. It is surveyed 9341 tests. Identification of isolates were carried out with use Vitek-2 and by method of mass spectrometry (Bruker Daltonik MALDI Biotyper). It was studied the effects of different disinfectants on NFB isolates. It was studied biofilm formation activity of stamms of bacteria before and after treatment different disinfectants .NFB can act as the Half Care -Associated Infections (HCAI) main potential activator in hospitals: on the importance in decreasing order of Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Acinetobacter baumanii found in people and on objects in offices. Strains of NFB were pan antibiotics rezistens. Possibility of use of mass spectrometry for carrying out the epidemiological analysis of cases of HCAI is discussed.

An analysis of acute intestinal infections morbidity among population of Sakha Republic (Yakutia) from 2005 through 2014 was performed. The sanitary and anti-epidemic measures, which prevent outbreak and spread of infection were evaluated.

The reasons and ways of entry of microorganisms and heavy metals in drinking water. Electron microscopy shows that the fungi Penicillium canescens leaches gold from waste deposits heavy metals and their predominantly on the cell wall, its surface layer of the cytoplasmic membrane, intercellular septum wall and conidia. It is assumed that the chlorine-resistant forms of microorganisms and cell fragments bearing heavy metals overcome the water treatment system and in drinking water tap, causing harm to human.

Analysis of effectiveness of medical examination of migrants on the territory of the Far Eastern Federal District was performed. From 2007 thorough 2014more than 785 000 of labor migrants was examined, among them 2547 migrants had infectious diseases including HIV infection in 575 patients (22.5%), tuberculosis in 1058 patients (41.5%) and sexually transmitted diseases in 917 patients (36%).

In 2013 Tomsk oblast of Russia experienced HIV outbreak with 5.9-fold increase of morbidity. Aim of this work was to analyse the specific molecular epidemiological situation with HIV dissemination in Tomsk oblast. Current HIV epidemic in TO is characterised by substitution of earlier predominant subtype A to СRF63_02A1, increase of genetic diversity of circulating viruses due to active recombination in HIV-1 population and appearance of 63_02A1/А HIV-1 URFs.

Antiretroviral treatment (ART) becomes the core element of contemporary specific HIV prevention arrangements. But its efficaciousness depends on a high level adherence above 95%. It takes the proper arrangement of both pre/post HIV test counseling and follow up observations to achieve and support such high adherence in HIV positive patients. The article gives coverage of predictive factors having concern with the successful achievement of high adherence to ART. There are given two forms of questionnaire able to optimize counseling to achieve and support the adherence. The authors pay heed to conceptual duality in the medical thoughts concerning the terms of compliance with and adherence to ART that results in improper and inadequate actions of HIV clinics personnel during the counseling and following up the patients. It is noticed the necessity to distinguish three consecutive kinds of adherence: to health support, to follow up observation, and, actually, to ART. The authors give guidance to achieve the high adherence taking into account the main predictors of it.

A comparative study of plasmid characteristics of Salmonella Enteritidis population in the three jurisdictions of the Far East was performed. Heterogeneity of microbe populations by plasmid characteristics was revealed and more than 90% of sporadic morbidity etiologically related to the 10 plasmid types of microbe was found. The etiological significance of plasmid types of microbes in the regions varied, but the leading role in the etiology of salmonellosis play three Salmonella Enteritidis plasmid types: 38 MDa, 38:1,4 MDa and 38:4,2 MDa. The main factors of the spread of salmonellosis in the Far East were considered. They are the local population of the microbe, circulating in local poultry farms, imported portions coming into regions with imported poultry products, and microbe migrations during transport of chickens breeding material. Recent migrations are crucial in maintaining the microbe heterogeneity and spreading of Salmonella.

A clinical laboratory analysis of intestinal infections among 42 1-, 2-, and 3-month-old children, hospitalized to infectious diseases department of regional clinical hospital in 2014, was performed. Some features of clinical course of infectious diarrhea were revealed; furthermore, the evaluation of treatment effectiveness was performed.

The result of preliminary investigation of parasitological studies of biological materials obtained from population and evaluation of parasitological status of basins of Amur Oblast are presented in this article. The circulation of etiological agents of clonorchiasis, metagonimiasis, nanophyetiasis in the basins of Amur Oblast was revealed. Human is not an obligatory host for the life cycle of parasites, and get infected after consumption of contaminated fish, especially in summer.

The question of the safety control relevance of the human environment objects, their assessment in the sanitary-parasitological monitoring is studied. There are given the differences in the interpretation of the results of the objects investigations at the control and supervisory measures and monitoring observations. The significance of the determining the viability of the revealed parasitic pathogens, as the criteria for safety of the environmental objects was accentuated. There was presented the approach to the assessing the safety of quality in connection with the probability of realization of ecological-parasitological risk factors. There was identified the perspective direction of sanitary parasitology - the development of methodological support and the formation of quantitative criteria for the risk of infection of the population with parasitic diseases.

The paper presents the clinical and laboratory aspects of parasitic associations in lambliosis. It is shown that the invasion Lamblia intestinalis often occurs in association with nematodes (enterobiosis, toxocarosis and ascariasis) and much less - with cestodosis.

Diphyllobothriasis is the most prevailing helminthiasis in Far North of the Russian Federation. Morbidity rate in Sakha (Yakutia) Republic is ten times higher than average morbidity rate in the Russian Federation. Infection occurs after consumption of raw fish, freshly salted fish caught in Lena River and its tributaries. The highest diphyllobothriasis morbidity rate was found among seamen of Lena United River Shipping Company.

From 2010 through 2014, 1134 children (from 2 to 14 years) residing in different districts of Khabarovsk Krai were examined for parasitic infections. Intestinal helminthiasis were found in 548 children (48.3%). The role of intestinal helminthiasis in etiopathogenesis of many somatic was confirmed.