The epidemiology of tick-borne human infections in the Russian Federation was analyzed. The presence of common vectors of various pathogens determines a high prevalence of combined natural foci of tick-borne infections. A comprehensive approach was substantiated to supervision, laboratory diagnosis and prevention of tick-borne infections in consideration of the degree of risk of infection of the population.

The epidemiological situation for natural-focal infectious diseases is described 2014 at the territory supervised by the Reference-Centre to monitoring for natural-focal bacterial and viral infectious diseases in Irkutsk Antiplague Research Institute of Rospotrebnadzor. The analysis is performed on the basis of data received from the Rospotrebnadzor’s Establishments of the Siberian - 12 Subjects, Far Eastern - 9 and Ural Federal Districts - 3. The volume of laboratory examinations during monitoring for these nosoforms is presented. It is shown the decrease of total number of the patients with natural-focal infections is observed. It is established that a high water in Priamure in 2013, in Sayany and Altai foothills in 2014 caused a serious material loss and considerably worsened a sanitary-and-hygienic situation in the suffered territories, but did not serve as the reason of essential epidemic complications for natural-focal infectious diseases in humans. As a whole, the epidemiological situation for natural-focal infectious diseases in 2014 remains calm and there are no objective preconditions for its deterioration in 2015.

The research contains materials describing the dispersion of ixodid ticks across the frontier areas with the Republic of Kazakhstan and the distinct characteristics of the taiga tick population cycles. There is a description of general focal tick typhus geography in Western Siberia and Kazakhstan. The work lists new types of tick typhus rickettsia group identified in different regions of Russia and Kazakhstan. Associated tick infection focus areas and development of differential laboratory diagnostics of diseases constitute the focus. An urgent issue is the rabies focus area in Western Siberia and Kazakhstan, which requires monitoring of foxes as the key hosts of the rabies virus.

The results of epizootiological surveillance, data on transmissible infectious disease morbidity and weather conditions recorded from 2013 through 2014 in southern climate zone of Khabarovsk Krai. The presence of Borrelia in natural focus, spectrum of pathogens in Ixodes ticks were evaluated.

A range of Ixodes pavlovskyi includes two geographically dissociated parts: the Altai and the Far East. On the territory of Western Siberia in the late XX - early XXI centuries in the anthropogenically transformed areas increasing I. pavlovskyi quantity in the proportion with I. persulcatus in zone of these two species cohabitation, and it is important from the perspective of possible epidemiological consequences. The purpose of this work is to analyze the structure complex of the species I. pavlovskyi and I. persulcatus dynamic in their cohabitation area in the south of Primorsky region. Previous analysis does not revealed a change in the share of I. pavlovskyi ticks communities on the mainland. On Reyneck island its quantity decreased and on Russian island, on which in the twentieth century I. pavlovskyi missed or was rare, this species quantity increased (till 35%). According to data for the years 2011-2014. not found any differences in the infestation of these two species by tick-borne encephalitis virus and Borrelia. Lower I. pavlovskyi aggressiveness towards humans suggests that changing in the structure of species complex will not cause deterioration of the epidemiological situation on the Russian island. However, in connection with increasing number of permanent resident population on in it and active tourists and vacationists, epidemiological surveillance on the island needs to be strengths.

Based on molecular genetic studies of 133 tick-borne encephalitis virus strains isolated from 1990 to 2014 in Altai, Western Siberia and Kazakhstan, the widespread of European subtype of tick-borne encephalitis virus in natural foci of mountain and plain areas of the Altai and steppe plains of the region was revealed.

Modern methods of Leptospira identifying including multilocus sequence typing and direct protein profiling using the technology of mass spectrometry with matrix-assisted laser desorption/ionization time of flight and division were tested. Irkutsk Antiplague Research Institute of Rospotrebnadzor Leptospira working collection checking revealed two strains with a taxonomic error and six strains with changes in the sucA gene sequences.

At present, special attention is attracted to research a compound from the group of biogenic amines (BA), which play an important role in neuroendocrine system of humans and animals. In addition, there are reports on the effects of asthma on microorganisms. In connection with these data, the aim of this work was to study the effect of biogenic amines on the growth of Yersinia pseudotuberculosis, pseudotuberculosis pathogen of humans and animals, as well as widespread in the environment. The studies showed a dose-dependent effect of BA on the growth and reproduction of bacteria.

The data regarding rabies epizootic situation in Russia and Ulyanovsk Oblast are presented in this study. The main role of red fox in transmission of rabies was highlighted. Several unresolved issues in organization and surveillance and prevention of rabies were pointed out.

This article describes fauna of Ixodes ticks and their vertebral hosts in the south of Primorsky Krai, an evaluation of some species of mammals as the providers of preimaginal stage of Ixodes ticks were performed. Data collected from 1987 through 1988 were analyzed.

This article presents the data collected from 2010 through 2014, regarding major environmental features and extremely dangerous natural focal infections infection rate among East European vole. The number of voles, reproduction and infection rates were evaluated using standard techniques. The highest number of voles was in Sovetskaya Gavan town and nearby townships. The circulation of hantavirus infection among animals of Sovetskaya Gavan district was shown.

The analysis of the situation of cholera in the Far East during the seventh pandemic was made with using modern molecular technologies. It was found, that the epidemiological onsets of cholera in the territory during the analyzed period is characterized by the registration of individual cases of introduction of infection, and as a result developing in two cases acute local outbreaks of cholera with the recovering of toxigenic pathogen from environmental objects, long-term detection of V. cholerae eltor in surface water in the satisfactory cholera period. Molecular-epidemiological analysis based on complex methodological approaches (amplification profiling, MLVA- PFGE- MLST-typing) isolates showed the ability to differentiate into separate groups according to their epidemiological significance and identified polymorphisms within these groups on the structure of individual loci, that determines the effectiveness of different approaches to identifying the causes of complications for cholera, clarifying the direction of the skid and pathways of the pathogen in the territory.

There is V. cholerae eltor clonal structure VNTR characteristic repoted. The strains were isolated from Primorsky, Khabarovsk territories and Sakhalin region during different epidemiological situation. The epidemic dangerous strains are characterized with high clonality and clustering that depend on the isolation place. Contrary, nontoxigenic V.cholerae strains are from surface water have higher population heterogeneity. The clusterisation that depends on the isolation place belongs to the last group in most cases.

А patient who got sick in Thailand, arrived to Russia on the fifth day from disease onset, despite hospitalization and intensive treatment he died from bilateral atypical pneumonia 3 days later. Legionella pneumophila was revealed as the etiological causes of pneumonia by bacteriological, serological, PCR and mass spectrometric studies of post-mortem samples.

Leishmaniasis is a natural-focal, transmissive disease occurs in countries with tropical and subtropical climate and spread by the bite of mosquitoes. The disease is found across Mediterranean region, Middle East, in the western part of Hindustan peninsula, Central Asia and Transcaucasia region. Last case of Leishmaniasis in Amur oblast was registered more than 20 years ago. That is why the knowledge of clinical manifestations of the disease, diagnostics and differential diagnostics will possible help to avoid diagnostic errors and perform adequate treatment.

This article describes for the first time a case of bubonic form of tularemia in the northern region of Amur Oblast (region of Baikal-Amur Mainline). A possible cause of infection was caught sable which bit a patient.