Influence of Bacillus anthracis with different plasmid composition on pathological changes and accumulation of cyclic nucleotides in thymus and spleen of experimental animals
Abstract
The ratio of cyclic adenosine monophosphate / cyclic guanosine monophosphate and pathological changes in immunocompetent organs (thymus, spleen) of white mice infected with Bacillus anthracis with different plasmid composition were studied. Differences in the action of B. anthracis on the functional state of cells of the immune system (differentiation and proliferation of cells), which depend on the plasmid composition of the sibyl ulcer microbe, were revealed. The presence of morphological changes in the immunocompetent organs of laboratory animals during experimental anthrax infection, manifested by varying degrees of severity of the pathological process and activation of the immune response, caused by the pXO1 + plasmid, was established.
About the Authors
V. I. Dubrovina
Irkutsk Antiplague Research Institute of Siberia and Far East of Rospotrebnadzor
Russian Federation
Russian Federation
Irkutsk
O. V. Yurieva
Irkutsk Antiplague Research Institute of Siberia and Far East of Rospotrebnadzor
Russian Federation
Russian Federation
Irkutsk
A. B. Pentecostnikova
Irkutsk Antiplague Research Institute of Siberia and Far East of Rospotrebnadzor
Russian Federation
Russian Federation
Irkutsk
T. P. Starovoitova
Irkutsk Antiplague Research Institute of Siberia and Far East of Rospotrebnadzor
Russian Federation
Russian Federation
Irkutsk
O. B. Kolesnikova
Irkutsk Antiplague Research Institute of Siberia and Far East of Rospotrebnadzor
Russian Federation
Russian Federation
Irkutsk
E. V. Kravets
Irkutsk Antiplague Research Institute of Siberia and Far East of Rospotrebnadzor
Russian Federation
Russian Federation
Irkutsk
T. A. Ivanova
Irkutsk Antiplague Research Institute of Siberia and Far East of Rospotrebnadzor
Russian Federation
Russian Federation
Irkutsk
S. V. Balakhonov
Irkutsk Antiplague Research Institute of Siberia and Far East of Rospotrebnadzor
Russian Federation
Russian Federation
Irkutsk
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Review
For citations:
Dubrovina V.I., Yurieva O.V., Pentecostnikova A.B., Starovoitova T.P., Kolesnikova O.B., Kravets E.V., Ivanova T.A., Balakhonov S.V. Influence of Bacillus anthracis with different plasmid composition on pathological changes and accumulation of cyclic nucleotides in thymus and spleen of experimental animals. Far Eastern Journal of Infectious Pathology. 2020;(39):106-110. (In Russ.)
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