SEROLOGICAL CHARACTERISTICS OF HUMAN PEGIVIRUS TYPE 1 (HEPATITIS G VIRUS) IN PEOPLE LIVING WITH HIV-INFECTION
Abstract
Course of HIV and human pegivurus type 1 (HPgV-1 previously known as hepatitis G virus) co-infection has a more favorable outcome compared with HIV mono-infection. Such patients often have a lower HIV viral load. Their life expectancy and quality of life are higher compared to HIV-positive patients without HPgV-1 co-infection. Regarding the observed data specific interest is drawn towards evaluating the prevalence of HPgV-1 markers among people living with HIV. The research investigated abundance of antibodies against HPgV-1 E2 glycoprotein in the blood serum of 295 HIV-infected patients. Control group included 160 apparently healthy people (with no indication on HBV and or HCV infection). Antibodies against HPgV-1 E2 glycoprotein were detected in 6.78% (95% CI: 3.91±9.65%) of the examined HIV-positive individuals. In the control group, the evaluated index equaled 5.0% (95% CI: 1.62±8.38%). No statistically significant differences were revealed between the two groups (χ2 Yates correction=0.3; p=0.58). Thereby prevalence of serological markers of HPgV-1 infection in both analyzed groups was relatively low. In order to execute a more detailed research it is necessary to conduct molecular-genetic analysis and reveal molecular-epidemiological peculiarities of HPgV-1 circulation in the Far Eastern federal district.
About the Authors
E. A. Bazykina
FBIS Khabarovsk research institute of epidemiology and microbiology of the Federal service for surveillance on consumers rights protection and human wellbeing
Russian Federation
Russian Federation
Khabarovsk
O. E. Trotsenko
FBIS Khabarovsk research institute of epidemiology and microbiology of the Federal service for surveillance on consumers rights protection and human wellbeing
Russian Federation
Russian Federation
Khabarovsk
T. B. Turkutyukov
FSBEI HI Pacific state medical university of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
FSBEI HI Pacific state medical university of the Ministry of Healthcare of the Russian Federation
L. А. Balakhontseva
FBIS Khabarovsk research institute of epidemiology and microbiology of the Federal service for surveillance on consumers rights protection and human wellbeing
Russian Federation
Russian Federation
Khabarovsk
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Review
For citations:
Bazykina E.A., Trotsenko O.E., Turkutyukov T.B., Balakhontseva L.А. SEROLOGICAL CHARACTERISTICS OF HUMAN PEGIVIRUS TYPE 1 (HEPATITIS G VIRUS) IN PEOPLE LIVING WITH HIV-INFECTION. Far Eastern Journal of Infectious Pathology. 2020;(38):80-83. (In Russ.)
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