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Far Eastern Journal of Infectious Pathology

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Molecular-epidemiologic analysis of enteroviruses circulating on the territory of the Far Eastern and Siberian Federal Districts of the Russian Federation including those that caused outbreaks of the disease

Abstract

Enteroviruses are spread ubiquitously and under certain circumstances can cause sporadic cases of the disease or breakouts of enterovirus infection (EVI) that have different clinical manifestations. Molecular-biological approach allowed to identify 32 enterovirus types that were circulating in the constituent entities of the Far Eastern and Siberian Federal Districts during year 2017. The most prevalent viruses that caused highest incidence were Coxsackie A-10, Coxsackie A-6 and Coxsackie A-9. The conducted evolutionary analysis allowed to identify 2 lineages of Coxsackie A-10 and 3 groups of Coxsackie A-6 that were presented as genotype D. Etiological origin of EVI breakouts in children organized communities in Irkutsk region and Krasnoyarsk region in 2017 were Coxsackie A-6, Coxsackie A-9 and ECHO-18. The obtained results of the phylogenetic research allowed us to suspect that these viruses were introduced on the territories of the Russian Federal Districts from the Southeast Asian nations. Absent levels of immunity against current viral serotypes among population of the Irkutsk and Krasnoyarsk regions lead to breakouts. The obtained data indicate on a necessity of ongoing molecular-epidemiological surveillance over enteroviruses in supervised territories.

About the Authors

E. Yu. Sapega
FBIS Khabarovsk scientific research institute of epidemiology and microbiology of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Khabarovsk



L. V. Butakova
FBIS Khabarovsk scientific research institute of epidemiology and microbiology of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Khabarovsk



O. E. Trotsenko
FBIS Khabarovsk scientific research institute of epidemiology and microbiology of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Khabarovsk



D. V. Goryaev
Krasnoyarsk region regional office of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Krasnoyarsk



G. M. Dmitrieva
Krasnoyarsk region regional office of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Krasnoyarsk



T. N. Detkovskaya
Primorsky region regional office of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Vladivostok



N. I. Zhdanova
Kamchatka region regional office of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Petropavlovsk-Kamchatsky



T. A. Zaitseva
Khabarovsk region regional office of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Khabarovsk



M. E. Ignatyeva
Republic Sakha (Yakutia) regional office of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Yakutsk



O. P. Kurganova
Amur region regional office of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Blagoveshchensk-on-Amur



P. V. Kopilov
Jewish Autonomous district regional office of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Birobidzhan



S. E. Lapa
Zabaikalsky region regional office of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Chita



A. N. Perezhogin
Irkutsk region regional office of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Irkutsk



A. A. Rubtsova
Magadan region regional office of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Magadan



O. A. Funtusova
Sakhalin region regional office of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Yuzhno-Sakhalinsk



S. S. Khankhareev
Buryatiya republic regional office of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Ulan-Ude



L. V. Shuchinov
Altai Republic regional office of the Federal Service for surveillance on consumers rights protection and human wellbeing (Rospotrebnadsor)
Russian Federation

Gorno-Altaysk



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Review

For citations:


Sapega E.Yu., Butakova L.V., Trotsenko O.E., Goryaev D.V., Dmitrieva G.M., Detkovskaya T.N., Zhdanova N.I., Zaitseva T.A., Ignatyeva M.E., Kurganova O.P., Kopilov P.V., Lapa S.E., Perezhogin A.N., Rubtsova A.A., Funtusova O.A., Khankhareev S.S., Shuchinov L.V. Molecular-epidemiologic analysis of enteroviruses circulating on the territory of the Far Eastern and Siberian Federal Districts of the Russian Federation including those that caused outbreaks of the disease. Far Eastern Journal of Infectious Pathology. 2018;(35):6-14. (In Russ.)

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ISSN 2073-2899 (Print)