COXSACKIEVIRUS A5 CIRCULATION IN THE EUROPEAN PART AND IN THE EAST OF RUSSIA
https://doi.org/10.62963/2073-2899-2024-46-28-32
Abstract
Over the past few years, the number of cases of HFMD diseases associated with Coxsackievirus A5 (CVA5) infection has increased worldwide. The detection rate of this virus has become comparable to the currently dominant pathogens: CVA6, CVA16, CVA10 and Enterovirus A71. The dynamics of CVA5 circulation in the European part and eastern regions of Russia in the period 2013-2023 is characterized. The genetic diversity and phylogenetic relationships of strains identified in the Russian Federation and other countries are studied. The virus was detected annually, with the exception of 2020, detection peaks were recorded in 2018 and 2023. The proportion of CVA5 in the structure of etiological agents of enterovirus infection averaged 4.27%, in the structure of identified Enterovirus A viruses – 7.25%. CVA5 infection was more often manifested in the form of acute respiratory disease 33.05%, herpangina – 22.88%, HFMD – 16.95%. The Russian CVA5 strains were characterized by genetic heterogeneity, manifested by the simultaneous circulation of viruses belonging to different genotypes and genovariants.
About the Authors
N. V. Ponomareva
FBIS Academician Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor (Federal Service on Surveillance and Consumer Rights Protection and Human Walfare)
Russian Federation
Russian Federation
Nizhny Novgorod
L. N. Golitsyna
FBIS Academician Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor (Federal Service on Surveillance and Consumer Rights Protection and Human Walfare)
Russian Federation
Russian Federation
Nizhny Novgorod
E. Yu. Sapega
FBIS Khabarovsk Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor
Russian Federation
Russian Federation
Khabarovsk
V. V. Zverev
FBIS Academician Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor (Federal Service on Surveillance and Consumer Rights Protection and Human Walfare)
Russian Federation
Russian Federation
Nizhny Novgorod
S. G. Selivanova
FBIS Academician Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor (Federal Service on Surveillance and Consumer Rights Protection and Human Walfare)
Russian Federation
Russian Federation
Nizhny Novgorod
L. V. Butakova
FBIS Khabarovsk Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor
Russian Federation
Russian Federation
Khabarovsk
O. E. Trotsenko
FBIS Khabarovsk Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor
Russian Federation
Russian Federation
Khabarovsk
N. A. Novikova
FBIS Academician Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology of Rospotrebnadzor (Federal Service on Surveillance and Consumer Rights Protection and Human Walfare)
Russian Federation
Russian Federation
Nizhny Novgorod
References
1. Голицына Л.Н., Фомина С.Г., Парфенова О.В. и др. Молекулярно-генетическая характеристика эпидемически значимых энтеровирусов вида А // Медицинский альманах. – 2013. – №2. – С.96-99.
2. Голицына Л.Н. Способ дифференциальной амплификации фрагмента области VP1 генома энтеровирусов видов Enterovirus A и Enterovirus B: Патент № 2743352, Российская Федерация // Бюллетень ФИПС «Изобретения. Полезные модели». – 2021. – № 5.
3. Заболеваемость, этиологическая структура и вопросы профилактики энтеровирусной (неполио) инфекции: Информационный бюллетень №1-11. – Нижний Новгород, 2014-2023 гг. – Доступно online: https://www.nniiem.ru/development/informanalit/evi.html.
4. Леонов А.В., Пономарева Н.В., Селиванова С.Г., Зверев В.В., Голицына Л.Н. Молекулярно-генетический мониторинг циркуляции вируса Коксаки А5 // Современные проблемы эпидемиологии, микробиологии и гигиены: Сборник материалов XV Всероссийской научно-практической конференции молодых ученых и специалистов Роспотребнадзора. Нижний Новгород, – 2023. – С. 254-258.
5. Dalldorf G. and Sickles G.M. Diagnostic Procedures for Virus and Rickettsial Diseases 2nd Edition / Am. Public Health Assoc., New York, 1953. –– P. 153.
6. Forero E.L., Knoester M., Gard L. et al. Changes in enterovirus epidemiology after easing of lockdown measures // J. Clin. Virol. – 2023. – 169:105617.
7. Kumar S., Stecher G. and Tamura K. MEGA7: Molecular Evolutionary Genetic Analysis version 7.0 for bigger datasets // Molecular Biology and Evolution. – 2016. – Vol.33. – P. 1870-1874.
8. Meng X. D., Tong Y., Wei Z. N. et al. Epidemical and etiological study on hand, foot and mouth disease following EV-A71 vaccination in Xiangyang, China // Scientific reports, 2020. – Vol. 10, № 1. – P. 1-11.
9. Mirand A., Cohen R., Bisseux M. et al. A large-scale outbreak of hand, foot and mouth disease, France, as at 28 September 2021 // Eurosurveillance. – 2021. – Vol. 26, №. 43. – P. 2100978.
10. Nix W.A, Oberste M.S, Pallansch M.A. Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens // Journal of Clinical Microbiology. – 2006. – Vol. 44, N8. – P. 2698-2704.
11. Park K., Lee B., Baek K. et al. Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children // Virology journal. – 2012. – Vol. 9. – P. 1-6.
12. Pham N. T. K., Thongprachum A., Trinh Q. D. et al. Detection and genetic characterization of enterovirus strains circulating among children with acute gastroenteritis in Japan during 2014–2016 // Infection, Genetics and Evolution. – 2018. – Vol. 61. – P. 16-19.
Review
For citations:
Ponomareva N.V., Golitsyna L.N., Sapega E.Yu., Zverev V.V., Selivanova S.G., Butakova L.V., Trotsenko O.E., Novikova N.A. COXSACKIEVIRUS A5 CIRCULATION IN THE EUROPEAN PART AND IN THE EAST OF RUSSIA. Far Eastern Journal of Infectious Pathology. 2024;(46):28-32. (In Russ.) https://doi.org/10.62963/2073-2899-2024-46-28-32
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