Preview

Far Eastern Journal of Infectious Pathology

Advanced search

FORMATION OF POPULATION IMMUNITY TO INFLUENZA VIRUSES IN PRE- AND POST- EPIDEMIC PERIODS IN LONG-TERM DYNAMICS AMONG THE POPULATION OF THE SVERDLOVSK REGION

https://doi.org/10.62963/2073-2899-2024-46-22-27

Abstract

The aim of the work was to evaluate the formation of population immunity to influenza in the pre- and post-epidemic periods in the long-term dynamics among the population of the Sverdlovsk region. Materials and methods: 2644 blood serum samples of donors living in the Sverdlovsk region were studied. The studies were carried out in the laboratory of FBUN FNIIVI "Virom" of Rospotrebnadzor by serologic method (RTGA) to determine protective antibody titers in blood sera. The data on the circulation of respiratory viruses were provided by the Center of Hygiene and Epidemiology in the Sverdlovsk region based on the results of the examination of patients with ARVI and influenza. Results: he lowest number of seropositive individuals with protective antibody titers (1≥40) to influenza A(HlNl) virus - 36.4-49.1% on the eve of the epidemic seasons 2015-2016, 2019-2020, 2020-2021, 2021-2022 - was detected, to influenza A(H3N2) virus - 38.0-50.0% in 2016-2017, 2018-2019, to influenza B virus - 40.4;45.1;34.5% in 2019-2020, 2020-2021, 2021-2022 respectively. At the end of the listed epidemic seasons, an increase in protective antibody titers was detected in accordance with the proportion of the above viruses. The exception was the seasons 2019-2020 and 2020-2021, when despite the minimum number of seropositive persons to influenza A(HlNl) virus, their number at the end of the season practically did not change (p>0.05), and PCR studies did not reveal the circulation of this virus in the population. This fact can be explained by the suppression of the mentioned virus circulating at this time by the epidemic variant of Wuhan strain SARS-CoV-2. Discussion: It is hypothesized that when the level of population immunity (PI) to influenza viruses was lowest before an epidemic upsurge caused by a particular influenza virus, the incidence rates of this virus in the population became higher when the epidemic occurred. Consequently, the immune layer of the population to circulating influenza viruses was in correlation with the activity of the epidemic process. Conclusion: the determination of the immune layer continues to be a tool for predicting the epidemic process in influenza. The conducted research proves its relevance.

About the Authors

S. V. Koltunov
The Center for Hygiene and Epidemiology in the Sverdlovsk Region
Russian Federation

Ekaterinburg



S. V. Romanov
The Center for Hygiene and Epidemiology in the Sverdlovsk Region
Russian Federation

Ekaterinburg



A. V. Ponomareva
Directorate of the Federal Service for Supervision of Consumer Rights protection and Human Welfare in the Sverdlovsk Region
Russian Federation

Ekaterinburg



I. A. Korotkova
Federal Budgetary Institution of Science "Federal Scientific Research Institute of Viral Infections "Virome" Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being
Russian Federation

Ekaterinburg



E. V. Bolgarova
Federal Budgetary Institution of Science "Federal Scientific Research Institute of Viral Infections "Virome" Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being
Russian Federation

Ekaterinburg



A. Yu. Markaryan
Federal Budgetary Institution of Science "Federal Scientific Research Institute of Viral Infections "Virome" Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being
Russian Federation

Ekaterinburg



A. V. Slobodenyuk
Federal State Budgetary Institution of Higher Professional Education «Urals State Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation

Ekaterinburg



Y. V. Grigorieva
Federal State Budgetary Institution of Higher Professional Education «Urals State Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation

Ekaterinburg



I. A. Malchikov
Federal Budgetary Institution of Science "Federal Scientific Research Institute of Viral Infections "Virome" Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being; Federal State Budgetary Institution of Higher Professional Education «Urals State Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation

Ekaterinburg



References

1. Ильичева ТН, Дурыманов АГ, Иванова ЕВ и др. Гуморальный иммунитет к гриппу и тяжелые случаи заболевания в эпидемическом сезоне 2018-2019 гг. // Медицинская иммунология. - 2019. - №21 (6). – С.1147-1154.

2. Коншина ОС, Соминина АА, Смородинцева ЕА и др. Результаты многолетнего изучения популяционного иммунитета к вирусам гриппа А(H1N1)pdm09, А(H3N2) и В у взрослого населения России // Инфекция и иммунитет. – 2017.- Т.7, №1. – С. 27-36.

3. Львов ДК, Бурцева ЕИ, Щелканов МЮ и др. Развитие эпидемии гриппа на отдельных территориях России и в странах Северного полушария в сезоне 2013–2014 гг. // Вопросы вирусологии. – 2015.- Т.60, №5. – С.11–16.

4. Мальчиков ИА, Колтунов СВ, Слободенюк АВ и др. Оценка напряженности коллективного иммунитета жителей г. Екатеринбурга и Свердловской области к вирусу гриппа в эпидемические периоды 2015-2017 гг. // Уральский медицинский журнал. – 2018.- №3 - С.115-117.

5. Мальчиков ИА, Слободенюк АВ, Маркарян АЮ и др. Популяционный иммунитет к гриппу у населения Свердловской области в эпидемический сезон 2018-19 гг. // Медицинский алфавит - 2020. - №18. – С.26-28.

6. Методические указания «Методы определения показателей качества иммунобиологических препаратов для профилактики и диагностики гриппа» МУ 3.3.2.1758-03 утверждены 28 сентября 2003 г.

7. Соминина АА, Смородинцева ЕА, Столяров ЛА и др. Совершенствование системы надзора за гриппом в российской федерации: основные результаты сигнального надзора за гриппом и другими острыми респираторными вирусными инфекциями // Эпидемиология и вакцинопрофилактика. – 2017. - №1 - С.7-15.

8. Шиповалов АВ, Дурыманов АГ, Петрова ОВ и др. Анализ популяционного иммунитета к гриппу накануне эпидемических сезонов в 2014 г. и 2015 г. // Журнал микробиологии, эпидемиологии и иммунологии – 2017. - №2.- С.553-560.

9. Biggerstaff M, Alper D, Dredze M et al. Results from the centers for disease control and preventions predict the 2013–2014 Influenza Season Challenge // BMC Infect Dis. - 2016 Jul. - №22(16). – P.357. doi: 10.1186/s12879-016-1669-x.

10. Hallmann-Szelińska E, Szymański K, Łuniewska K et al. Hemagg-lutination inhibition antibody titers as a correlate of protection against influenza disease in the 2018/2019 epidemic season in Poland. // Acta Biochim Pol. – 2020 Mar 17. - №67(1). - P. 93-98. doi: 10.18388/abp.2020_5088.

11. Han AX, Maurer-Stroh S, Russell CA. Individual immune selection pressure has limited impact on seasonal influenza virus evolution // Nat. Ecol. Evol.- 2019 Feb. - №3(2). – Р.302-311. doi: 10.1038/s41559-018-0741-x. Epub 2018 Dec 3.

12. Ivanova VT, Matiushina RO, Slepushkin AN et al. Epidemic strains influenza viruses A and B in the 2005-2006 season in Russia // Vopr Virusol. - 2008 Jul-Aug. - №53 (4). - Р.13-18.

13. Krasnova EI, Karpovich G S, Provorova VV et al. Influenza in COVID-19 pandemic, epidemiological characteristics, approaches to vaccination // Lechaschy Vrach. - 2021. - №4 (24). – Р.50-56.

14. Krauland MG, Galloway DD, Raviotta JM et al. Impact of Low Rates of Influenza on Next-Season Influenza Infections // J. Prev Med. - 2022 Apr. - №62 (4). - Р.503-510. doi: 10.1016/j.amepre.2021.11.007. Epub 2022 Feb 24.

15. Lee VJ, Chen MI, Yap J et al. Comparability of different methods for estimating influenza infection rates over a single epidemic wave // Am J. Epidemiol - 2011. - №174. - Р.468‐478.

16. Morales KF, Paget J, Spreeuwenberg P. Possible explanations for why some countries were harder hit by the pandemic influenza virus in 2009 - a global mortality impact modeling study BMC // Infect Dis. - 2017 Sep. 25. - №17(1). - Р.642. doi: 10.1186/s12879-017-2730-0.

17. Petrova VN, Russell CA. Nat. Rev. // Microbiol. - 2018 Jan. - №16(1). - Р.47-60. doi: 10.1038/nrmicro.2017.118. Epub 2017 Oct 30.


Review

For citations:


Koltunov S.V., Romanov S.V., Ponomareva A.V., Korotkova I.A., Bolgarova E.V., Markaryan A.Yu., Slobodenyuk A.V., Grigorieva Y.V., Malchikov I.A. FORMATION OF POPULATION IMMUNITY TO INFLUENZA VIRUSES IN PRE- AND POST- EPIDEMIC PERIODS IN LONG-TERM DYNAMICS AMONG THE POPULATION OF THE SVERDLOVSK REGION. Far Eastern Journal of Infectious Pathology. 2024;(46):22-27. (In Russ.) https://doi.org/10.62963/2073-2899-2024-46-22-27

Views: 10


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2073-2899 (Print)