FORMATION OF POPULATION IMMUNITY TO INFLUENZA VIRUSES IN PRE- AND POST- EPIDEMIC PERIODS IN LONG-TERM DYNAMICS AMONG THE POPULATION OF THE SVERDLOVSK REGION
https://doi.org/10.62963/2073-2899-2024-46-22-27
Abstract
The aim of the work was to evaluate the formation of population immunity to influenza in the pre- and post-epidemic periods in the long-term dynamics among the population of the Sverdlovsk region. Materials and methods: 2644 blood serum samples of donors living in the Sverdlovsk region were studied. The studies were carried out in the laboratory of FBUN FNIIVI "Virom" of Rospotrebnadzor by serologic method (RTGA) to determine protective antibody titers in blood sera. The data on the circulation of respiratory viruses were provided by the Center of Hygiene and Epidemiology in the Sverdlovsk region based on the results of the examination of patients with ARVI and influenza. Results: he lowest number of seropositive individuals with protective antibody titers (1≥40) to influenza A(HlNl) virus - 36.4-49.1% on the eve of the epidemic seasons 2015-2016, 2019-2020, 2020-2021, 2021-2022 - was detected, to influenza A(H3N2) virus - 38.0-50.0% in 2016-2017, 2018-2019, to influenza B virus - 40.4;45.1;34.5% in 2019-2020, 2020-2021, 2021-2022 respectively. At the end of the listed epidemic seasons, an increase in protective antibody titers was detected in accordance with the proportion of the above viruses. The exception was the seasons 2019-2020 and 2020-2021, when despite the minimum number of seropositive persons to influenza A(HlNl) virus, their number at the end of the season practically did not change (p>0.05), and PCR studies did not reveal the circulation of this virus in the population. This fact can be explained by the suppression of the mentioned virus circulating at this time by the epidemic variant of Wuhan strain SARS-CoV-2. Discussion: It is hypothesized that when the level of population immunity (PI) to influenza viruses was lowest before an epidemic upsurge caused by a particular influenza virus, the incidence rates of this virus in the population became higher when the epidemic occurred. Consequently, the immune layer of the population to circulating influenza viruses was in correlation with the activity of the epidemic process. Conclusion: the determination of the immune layer continues to be a tool for predicting the epidemic process in influenza. The conducted research proves its relevance.
About the Authors
S. V. KoltunovRussian Federation
Ekaterinburg
S. V. Romanov
Russian Federation
Ekaterinburg
A. V. Ponomareva
Russian Federation
Ekaterinburg
I. A. Korotkova
Russian Federation
Ekaterinburg
E. V. Bolgarova
Russian Federation
Ekaterinburg
A. Yu. Markaryan
Russian Federation
Ekaterinburg
A. V. Slobodenyuk
Russian Federation
Ekaterinburg
Y. V. Grigorieva
Russian Federation
Ekaterinburg
I. A. Malchikov
Russian Federation
Ekaterinburg
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Review
For citations:
Koltunov S.V., Romanov S.V., Ponomareva A.V., Korotkova I.A., Bolgarova E.V., Markaryan A.Yu., Slobodenyuk A.V., Grigorieva Y.V., Malchikov I.A. FORMATION OF POPULATION IMMUNITY TO INFLUENZA VIRUSES IN PRE- AND POST- EPIDEMIC PERIODS IN LONG-TERM DYNAMICS AMONG THE POPULATION OF THE SVERDLOVSK REGION. Far Eastern Journal of Infectious Pathology. 2024;(46):22-27. (In Russ.) https://doi.org/10.62963/2073-2899-2024-46-22-27