DISEASES AND CONDITIONS ASSOCIATED WITH HUMAN HERPES VIRUS TYPE 6
Abstract
Diseases and conditions caused by human herpes virus type 6 are widespread, clinically diverse, often severe and require differential diagnosis and appropriate treatment. The literature review presents the pathogenetic, clinical and laboratory aspects of these diseases and conditions. Human herpes virus type 6 has two subtypes 6A and 6B, which differ from each other in biological properties, epidemiological characteristics, tropism for certain cells and the spectrum of pathological changes caused. Subtype 6A is involved in the development of epilepsy, multiple sclerosis, graftversus-host disease in organ recipients, and the progression of HIV infection. Primary infection with subtype 6B may result in roseola, acute fever without rash with febrile seizures, or encephalitis. Human herpes virus type 6 is capable of integrating into telomeres of somatic chromosomes, which leads to its hereditary transmission. Human herpes virus type 6 has protein U94, which contributes to the latency of the virus and suppresses the immune response.
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Starostina V.I. DISEASES AND CONDITIONS ASSOCIATED WITH HUMAN HERPES VIRUS TYPE 6. Far Eastern Journal of Infectious Pathology. 2023;(45):99-106. (In Russ.)
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