ROTAVIRUS INFECTION IN THE KHABAROVSK KRAI

Epidemiological analysis of rotavirus infection incidence was carried out and results of molecular genetic monitoring of rotaviruses circulating in the Khabarovsk krai during year 2022 were analyzed. It was established that rotavirus infection incidence rate in the year 2022 was slightly higher than longterm average level calculated for the period of observation that included years 2010–2019 (92.3 and 90.5 per 100 000 population, respectively). Predominance of preschool children was revealed among infected patients. Four outbreaks of rotavirus infection were registered in children's educational institutions in the year 2022. Molecular genetic analysis of pathogens found in foci of the outbreaks revealed circulation of three prevalent G-genotype rotaviruses: G9, G4 and G3. Phylogenetic analysis of rotavirus A genotype G9 indicated their possible importation from the countries of Southeast Asia when analysis of rotavirus A genotype G3 strains allowed to classify them as reassortants. Other rotavirus strains obtained from the foci of the disease outbreaks located the Khabarovsk krai were typed as P[8]-3 lineage in accordance with P-genotype strains. Regular monitoring of rotaviruses carried out against the background of continuous epidemiological analysis of incidence makes it possible describe the epidemic process of rotavirus infection in a specific territory more accurately.

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