An analysis of the current situation for the development of the HIV epidemic in the Tomsk oblast
Abstract
In 2013 Tomsk oblast of Russia experienced HIV outbreak with 5.9-fold increase of morbidity. Aim of this work was to analyse the specific molecular epidemiological situation with HIV dissemination in Tomsk oblast. Current HIV epidemic in TO is characterised by substitution of earlier predominant subtype A to СRF63_02A1, increase of genetic diversity of circulating viruses due to active recombination in HIV-1 population and appearance of 63_02A1/А HIV-1 URFs.
About the Authors
N. M. Gashnikova
Department of Retroviruses, State research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
A. V. Totmenin
Department of Retroviruses, State research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
D. P. Zyryanova
Department of Retroviruses, State research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
E. M. Astahova
Department of Retroviruses, State research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
V. V. Ivlev
Department of Retroviruses, State research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
M. P. Gashnikova
Department of Retroviruses, State research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
T. N. Ismailova
Tomsk Regional Center for Prevention and Control of AIDS and Other Infectious Diseases
Russian Federation
Russian Federation
A. S. Chernov
Tomsk Regional Center for Prevention and Control of AIDS and Other Infectious Diseases
Russian Federation
Russian Federation
V. N. Mikheev
Tomsk Regional Center for Prevention and Control of AIDS and Other Infectious Diseases
Russian Federation
Russian Federation
References
1. Baryshev PB, Bogachev VV, Gashnikova NM. Genetic characterization of an isolate of HIV type 1 AG recombinant form circulating in Siberia, Russia. Archives of Virology. 2012;157(12):2335-2341
2. Baryshev PB, Bogachev VV, Gashnikova NM. The HIV-1 Genetic Diversity in Russia: CRF63_02A1, a New HIV-1 Genetic Variant Spreading in Siberia. AIDS Research and Human Retroviruses. doi:10.1089/aid.2013.0196
3. Bogachev VV, Totmenin AV, Baryshev PB, et al.: Molecular-genetic characteristic of HIV-1 A and B subtypes variants isolated in Novosibirsk region. Zh. Microbiol. 2012;6:45-52.
4. Gashnikova NM, Safronov PF, Nikonorova YuV, et al. Properties of CRF02_AG HIV-1 isolates circulating in Novosibirsk region. Zh. Mikrobiol. 2011;3:38-43.
5. Hemelaar J, Gouws E, Ghys PD, Osmanov S. Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004. AIDS, 2006;.20:W13-23.
6. Riva C, Romano L, Saladini F, et al.: Identification of a possible ancestor of the subtype A1 HIV Type 1 variant circulating in the former Soviet Union. AIDS Res Hum Retroviruses. 2008;24(10):1319-1325.
7. Robertson DL, Anderson, J.A. Bradac JA et al.: HIV-1 nomenclature proposal. Science. 2000;288:55-56.
8. Tamura K., Dudley J., Nei M., Kumar S. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol. Biol. Evol. 2007, 24: 1596-1599.
9. Thomos MM, de Parga EV, Vinogradova A, et al.: New insights into the oring of the HIV type 1 subtype A epidemic in former Soviet Union’s countries derived from sequence analyses of preepidemically transmitted viruses. AIDS Res Hum Retroviruses. 2007;23(12):1599-1604.
Review
For citations:
Gashnikova N.M., Totmenin A.V., Zyryanova D.P., Astahova E.M., Ivlev V.V., Gashnikova M.P., Ismailova T.N., Chernov A.S., Mikheev V.N. An analysis of the current situation for the development of the HIV epidemic in the Tomsk oblast. Far Eastern Journal of Infectious Pathology. 2015;(29):62-64. (In Russ.)
Views:
166
Email this article 