Investigation of HIV-1 diversity in the integrase coding region
Abstract
The AIDS epidemic in Russia has unique features, showing co-circulation of HIV-1 subtypes A, B and CRF63_02A1. We have characterized the HIV-1 genetic diversity and natural polymorphisms at the integrase coding region from 55 plasma specimens collected in 2015 from HIV-1-infected patients in Siberian region. This study indicates an evolving HIV-1 epidemic in Russia with recombinant viruses; pretreatment HIV drug resistance was 7.3% and the occurrence of natural polymorphism in the IN region was subtype or CRF dependent.
About the Authors
N. M. Gashnikova
Department of Retroviruses, State research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
A. V. Totmenin
Department of Retroviruses, State research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
V. V. Ivlev
Department of Retroviruses, State research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
D. P. Zyryanova
Department of Retroviruses, State research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
E. M. Astahova
Department of Retroviruses, State research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
M. P. Gashnikova
Department of Retroviruses, State research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
T. N. Ismailova
Tomsk Regional Center for Prevention and Control of AIDS and Other Infectious Diseases
Russian Federation
Russian Federation
A. S. Chernov
Tomsk Regional Center for Prevention and Control of AIDS and Other Infectious Diseases
Russian Federation
Russian Federation
V. N. Mikheev
Department of Retroviruses, State research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
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Review
For citations:
Gashnikova N.M., Totmenin A.V., Ivlev V.V., Zyryanova D.P., Astahova E.M., Gashnikova M.P., Ismailova T.N., Chernov A.S., Mikheev V.N. Investigation of HIV-1 diversity in the integrase coding region. Far Eastern Journal of Infectious Pathology. 2015;(28):58-61. (In Russ.)
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