Assessment of the epidemiological risk strains of non-polio enteroviruses circulating among the population, the results of molecular-genetic
Abstract
The results of monthly 5-years molecular genetic monitoring of nonpoliomyelitis enteroviruses (NPEV) incidence in an indicator group of asymptomatic 3-to-6-years-old virus carriers living in a large industrial centre allowed to reveal a discrepancy between the spikes of NPEV isolation rate from asymptomatic children and the seasonal spikes of enterovirus aseptic meningitis (EVAM) morbidity. Significant difference was observed between the spectra of enteroviral serotypes detected among healthy individuals and the spectra of serotypes detected among EVAM patients. The data obtained indicate that neither the incidence of asymptomatic virus carriers nor the spectrum of NPEV serotypes detected in healthy individuals can be used as a reliable prognostic indicator for epidemic surveillance. The inverse relationship between the proportion of a specific NPEV serotype detected in the CSF samples from EVAM patients and the frequency of its detection among apparently healthy individuals with asymptomatic viral infection from the indicator group provides an estimate for the virulence and epidemic significance of circulating human NPEV strains.
About the Authors
A. G. Sergeev
Federal budgetary institution of science "Yekaterinburg research Institute of viral infections" of the Federal service for supervision of consumer rights protection and human welfare
Russian Federation
Russian Federation
A. V. Ustyuzhanin
State budgetary educational institution of higher professional education "Ural state medical University" Ministry of healthcare of the Russian Federation
Russian Federation
Russian Federation
A. V. Rezaikin
Federal budgetary institution of science "Yekaterinburg research Institute of viral infections" of the Federal service for supervision of consumer rights protection and human welfare
Russian Federation
Russian Federation
A. V. Alimov
Federal budgetary institution of science "Yekaterinburg research Institute of viral infections" of the Federal service for supervision of consumer rights protection and human welfare
Russian Federation
Russian Federation
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Review
For citations:
Sergeev A.G., Ustyuzhanin A.V., Rezaikin A.V., Alimov A.V. Assessment of the epidemiological risk strains of non-polio enteroviruses circulating among the population, the results of molecular-genetic. Far Eastern Journal of Infectious Pathology. 2015;(28):20-26. (In Russ.)
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