CIRCULATING RECOMBINANT FORMS OF HIV-1 IN CONSTITUENT ENTITIES OF THE FAR EASTERN FEDERAL DISTRICT
Abstract
Molecular-epidemiological analysis showed that despite domination of sub-subtype A6 in the Far Eastern Federal district (FEFD) genetic profile of HIV-infection was diverse. A total number of 91 recombinant forms were found among people living with HIV. Seven types of circulating recombinant forms (CRF) and one unique recombinant form (URF) of HIV-1 were identified: CRF03_AB – 4 (4.4±2.2%), CRF02_AG – 14 (15.6±3.8%), CRF63_02A1 – 65 (71.1±4.8%), CRF11_cpx – 1 (1.1±1.1%), CRF01_AE – 4 (4.4±2.2%), CRF09_cpx 1(1.1±1.1%), CRF07_BC– 1 (1.1±1.1%), URF63_02A– 1 (1.1±1.1%). Moderate abundance of circulating recombinant forms was revealed in Jewish autonomous district and Amur oblast. Cause of an increase of HIV-1 recombinant forms spread in the FEFD can be a result of high internal and external migration.
About the Authors
V. O. KotovaRussian Federation
L. A. Balakhontseva
Russian Federation
E. A. Bazykina
Russian Federation
O. E. Trotsenko
Russian Federation
References
1. World Health Organization. Global report: UNAIDS report on the global AIDS epidemic 2020. [Electronic resource]. Available from: (http://www.unaids.org/en/resources/documents/2020/unaids-data2020).
2. Справка Федерального научно-методического центра по профилактике и борьбе со СПИДом ФБУН Центрального НИИ эпидемиологии Роспотребнадзора «ВИЧ-инфекция в Российской Федерации на 31.12.2020 г.».
3. Ramirez BC, Simon-Loriere E, Galetto R, Negroni M. Implications of recombination for HIV diversity // Virus research. 2008; 134(1–2):64–73. https://doi.org/10.1016/j.virusres.2008.01.007PMID:18308413.
4. Konings FA, Burda ST, Urbanski MM, Zhong P, Nadas A, Nyambi PN. Human immunodeficiency virus type1 (HIV-1) circulating recombinant form 02_AG (CRF02_AG) has a higher in vitro replicative capacity than its parental subtypes A and G // J Med Virol.2006; 78(5):523–34. Epub 2006/03/24. https://doi.org/10.1002/jmv.20572PMID:16555291.
5. Nora T, Charpentier C, Tenaillon O, Hoede C, Clavel F, Hance AJ. Contribution of recombination to the evolution of human immunodeficiency viruses expressing resistance to antiretroviral treatment //Journal of virology.2007;81(14):76208. https://doi.org/10.1128/JVI.0008307PMID:17494080.
6. Turk G, Carobene MG. Deciphering How HIV-1 Intersubtype Recombination Shapes Viral Fitness and Disease Progression. EBioMedicine.2015;2(3):188-9. https://doi.org/10.1016/j.ebiom.2015.02.011P MID:26137559.
7. Robertson D.L., Anderson J.P., Bradac J.A. et al. HIV-1 nomenclature proposal // Science. – 2000. – Vol. 288 – N. 5463. – P. 55–56.
8. Arien K.K., Vanham G., Arts E.J. Is HIV-1 evolving to a less virulent formin humans? Nat Rev Microbiol. 2007; 5(2):141–51.
9. Los Alamos Database. HIV Circulating Recombinant Forms (CRFs). https://http://www.hiv.lanl.gov/content/sequence/HIV/CRFs/CRFs.html. Accessed 2021 April.
10. Hemelaar J. Implications of HIV diversity for the HIV-1 pandemic // Journal of Infections. 2013; 66: 391–400.
11. Hemelaar J, Elangovan R, Yun J, Dickson-Tetteh L, Fleminger I, Kirtley S, et al. Global and regional molecular epidemiology of HIV-1, 1990–2015: a systematic review, global survey, and trend analysis // Lancet Infect Dis.2019;19(2):143–55. https://doi.org/10.1016/S1473-3099(18)30647-9 PMID:30509777.
12. Chow W.Z., Takebe Y., Syafina N.E., Prakasa M.S., Chan K.G., Abed Al-Darraji H.A., Koh C., Kamarulzaman A., Tee K.K. A newly emerging HIV-1 recombinant lineage (CRF58_01B) disseminating among people who inject drugs in Malaysia // PLoSONE, 2014. Vol.9, N 1: e85250.
13. Казеннова Е.В., Лаповок И.А., Васильев А.В., Лага В.Ю., Грезина Л.А., Волова Л.Ю. и др. Проблемы субтипирования ВИЧ-1на основе анализа гена pol и способы их разрешения // ВИЧ-инфекция и иммуносупрессии. 2010; 3 (2): 42–48.
14. Tamura K., Stecher G., Peterson D., Filipski A., Kumar S. MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0. Molecular Biology and Evolution. 2013; (30): 2725-29.
15. Казеннова Е.В., Бронникова А.В., Кузин С.Н., Кириллова И.Л., Ершова О.Н., Афанасьева Л.Р. и др. Молекулярно-генетическая характеристика вариантов ВИЧ-1, циркулирующих в г. Череповце Вологодской области: второй случай эпидемической вспышки, вызванной рекомбинантом gagA envB // Вопросы вирусологии. – 2008. Т.53, №5. С.23-27.
16. Bobkov A., Kazennova E., Selimova L., Bobkova M., Khanina T., Ladnaya N., et al. A sudden epidemic of HIV type 1 among injecting drug users in the former Soviet Union: Identification of subtype A, subtype B, and novel gagA/envB recombinants. AIDS Res // Hum. Retroviruses. – 1998. – Vol.14, №8. – Р.669-676.
17. Liitsola K., Tashkinova I., Laukkanen T., Korovina G., Smolskaja T., Momot O. HIV-1 genetic subtype A/B recombinant strain causing an explosive epidemic in injecting drug users in Kaliningrad //AIDS. —1998. —Vol.12. —P. 1907–1919.
18. Wilbe K., Casper C., Albert J., Leitner T. Identification of two CRF11-cpxgenomes and two preliminary representatives of a new circulating recombinant form (CRF13_cpx) of HIV type 1 in Cameroon //AIDS Res. Hum. Retroviruses. 2002; 18(12): 849-56. Doi: https://doi.org/10.1089/08892220260190326
19. Montavon C., Vergne L., Bourgeois A., Mpoudi-Ngole E., Malonga-Mouellet G., Butel C., et al. Identification of a new circulating recombinant form of HIV type 1, CRF11-cpx, involving subtypes A, G, J, and CRF01-AE, in Central Africa // AIDS Res. Hum. Retroviruses. 2002; 18(3): 231-6. Doi: https://doi.org/10.1089/08892220252781301.
20. Brodine SK, Starkey MJ, Shaffer RA, Ito SI, Tasker SA, Barile AJ, Tamminga CL, Stephan KT, Aronson NE, Fraser SL, Wallace MR, Wegner SA, Mascola JR, McCutchan FE. Diverse HIV-1 subtypes and clinical, laboratory and behavioral factors in a recently infected US military cohort // AIDS. 2003 Nov 21;17(17):2521-7. doi: 10.1097/00002030-200311210-00016. PMID: 14600525.
21. McCutchan FE. Understanding the genetic diversity of HIV-1 // AIDS. 2000;14 Suppl 3:S31-44. PMID: 11086847.
22. Su L, Graf M, Zhang Y, von Briesen H, Xing H, Köstler J, Melzl H, Wolf H, Shao Y, Wagner R. Characterization of a virtually full-length human immunodeficiency virus type 1 genome of a prevalent intersubtype (C/B') recombinant strain in China // J Virol. 2000 Dec;74(23):11367-76. doi: 10.1128/jvi.74.23.11367-11376.2000. PMID: 11070037; PMCID: PMC113242.
23. Baryshev P.B., Bogachev V.V., Gashnikova N.M. Genetic characterization of an isolate of HIV type 1 AG recombinant form circulating in Siberia, Russia. Arch. Virol. 2012; 157(12): 2335-41. Doi: https://doi.org/10.1007/s00705-012-1442-4.
24. Baryshev PB, Bogachev VV, Gashnikova NM. HIV-1 genetic diversity in Russia: CRF63_02A1, a new HIV type 1 genetic variant spreading in Siberia. AIDS Res Hum Retroviruses. 2014 Jun;30(6):592-7. doi: 10.1089/aid.2013.0196. Epub 2014 Feb 6. PMID: 24279614; PMCID: PMC4046202.
Review
For citations:
Kotova V.O., Balakhontseva L.A., Bazykina E.A., Trotsenko O.E. CIRCULATING RECOMBINANT FORMS OF HIV-1 IN CONSTITUENT ENTITIES OF THE FAR EASTERN FEDERAL DISTRICT. Far Eastern Journal of Infectious Pathology. 2021;(40):79-87. (In Russ.)