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ISOLATION OF A RARE PATHOGEN CHRYSEOBACTERIUM INDOLOGENES WITH UNSPECIFIED CLINICAL SIGNIFICANCE IN PATIENTS WITH PNEUMONIA

https://doi.org/10.62963/2073-2899-2025-48-15-23

Abstract

Chryseobacterium indologenes (C. indologenes) is a rare and poorly studied pathogen from the group of non-fermenting Gram-negative bacteria (NFGB), which needs to be justified clinically. The aim of the study: toanalyse the detectability of C. indologenes strains from different biomaterial in pneumonia and the level of resistance to antimicrobial agents (AMA), as well as to substantiate the clinical significance of the rare pathogen. Materials and Methods. The materials for the study were 1740 clinical samples (744 – macrophages, 561 – nasopharyngeal swabs, 435 – autopsy material) obtained from pneumonia patients hospitalised in Khabarovsk hospitals during the COVID-19 pandemic (2020-2022). The study was performed using the classical bacteriological method. Identification of the pathogen was carried out using a Vitek 2 Compact 30 bacterial analyser, and clarifying identification was carried out using a Vitek MS mass spectrometer. Determination of sensitivity to AMPs was performed by disc-diffusion method and in a Vitek 2 Compact 30 analyser. Results. The cumulative detection rate of CSF was 17,3% (301 isolates from 1740 clinical specimens). The most frequent isolation of CSF was from autopsy material (31,7% of cases), less frequently from sputum (13,8%) and nasopharyngeal swabs (10,7%). Acinetobacter baumanii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia were isolated most frequently. The total isolation rate of C. indologenes was 0,5% (8 isolates from 1740 samples). This pathogen was isolated most frequently from nasopharyngeal swabs (1,1%) and least frequently from sputum (0,3%). The pathogen was not isolated from autopsy material during this period of observation. The level of resistance of isolates to AMP ranged from 50 to 100%. Clinical and laboratory characteristics of 8 cases of C. indologenes detection in patients with pneumonia are presented. Bacteriological examination in 6 out of 8 patients revealed two, three, four-component bacterial associations in clinical samples. In single patients from sputum the pathogen was isolated in high titre (105 ) on the day of admission to the hospital, in a later period (2024) C. indologenes was isolated from autopsy material. Conclusion. These observations support the significance of C. indologenes as a potential pathogen.

About the Authors

A. O. Golubeva
Khabarovsk Research Institute of Epidemiology and Microbiology of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)
Russian Federation

Khabarovsk



A. P. Bondarenko
Khabarovsk Research Institute of Epidemiology and Microbiology of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)
Russian Federation

Khabarovsk



O. E. Trotsenko
Khabarovsk Research Institute of Epidemiology and Microbiology of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)
Russian Federation

Khabarovsk



O. N. Ogienko
Khabarovsk Research Institute of Epidemiology and Microbiology of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)
Russian Federation

Khabarovsk



Е. K. Taran
Regional Clinical Hospital named after I.I. Professor S.I. Sergeev
Russian Federation

Khabarovsk



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For citations:


Golubeva A.O., Bondarenko A.P., Trotsenko O.E., Ogienko O.N., Taran Е.K. ISOLATION OF A RARE PATHOGEN CHRYSEOBACTERIUM INDOLOGENES WITH UNSPECIFIED CLINICAL SIGNIFICANCE IN PATIENTS WITH PNEUMONIA. Far Eastern Journal of Infectious Pathology. 2025;(48):15-23. (In Russ.) https://doi.org/10.62963/2073-2899-2025-48-15-23

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